NETWORK-BASED CLUSTERING UNVEILS INTERCONNECTED LANDSCAPES OF GENOMIC AND CLINICAL FEATURES ACROSS MYELOID MALIGNANCIES

Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies

Abstract Myeloid malignancies exhibit considerable heterogeneity with overlapping clinical and genetic features among subtypes.We present a data-driven approach that integrates mutational features and clinical covariates at diagnosis within networks of their probabilistic relationships, enabling the discovery of patient subgroups.A key strength is

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In Vitro Activities of Oxazolidinone Antibiotics Alone and in Combination with C-TEMPO against Methicillin-Resistant Staphylococcus aureus Biofilms

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a global health concern.The propensity of MRSA to form biofilms is a significant contributor to its pathogenicity.Strategies to treat biofilms often involve small molecules that disperse the biofilm into planktonic cells.Linezolid and, by extension, theoxazolidinones have b

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Bone Marrow Mesenchymal Stem Cells and Electroacupuncture Downregulate the Inhibitor Molecules and Promote the Axonal Regeneration in the Transected Spinal Cord of Rats

Our previous study has reported that electroacupuncture (EA) promotes survival, differentiation of bone marrow mesenchymal usadisk website stem cells (MSCs), and functional improvement in spinal cord-transected rats.In this study, we further investigated the structural bases of this functional improvement and the potential mechanisms of axonal rege

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DNA Protective Activity of Peels of Some Vegetables Wastes

The present study was conducted usadisk website by using kitchen wastes like peels of different vegetables e.g.cucumber, potato, carrot, chickpea, cauliflower and pea, to evaluate the phytochemical constituents, DNA protection ability and free radicals scavenging activity.Phytochemicals tests showed the presence of carbohydrates, amino acids, glyco

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